Peptides function as activators to stimulate the synthesis of major constituents of the skin such as collagen. How Can You Increase Collagen Synthesis? Collagen is a primary component in the connective tissues, such as tendons and ligaments. It is used extensively in the extracellular matrix, which forms the basis for most connective tissue. Transcription (in … View abstract. ; Vitamin C reverses sun damage, boosts collagen synthesis… Supplements. In the dermis, peptides are able to enter the skin cell and interact with specific proteins to signal the upregulation of collagen synthesis. 2019;29(5):526-531. Collagen synthesis refers to the process of collagen … Int J Sport Nutr Exerc Metab. Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. Collagen synthesis is a multi-step procedure requiring the use of many different structures both within and outside of fibroblasts (special collagen-producing cells within connective tissue). Supplemental intake of the following can boost collagen production: Retinol is a derivative of vitamin A which boosts collagen synthesis and speeds up cell turnover for youthful looking skin.